ZygoDx® range of diagnostic tests for mucormycosis

Mucorales Lateral-Flow Tests

ISCA has developed a lateral-flow device for mucormycosis, the second most common mould disease of humans after aspergillosis. The test uses a monoclonal antibody KC9 specific to Rhizopus arrhizus, the principal global agent of ‘black fungus’ disease, and responsible for the majority of life-threatening rhino-orbital-cerebral, pulmonary and disseminated infections in humans.

We have also developed a pan-Mucorales-specific lateral-flow device that detects all agents of mucormycosis including Apophysomyces, Cunninghamella, Lichtheimia, Mucor, Rhizomucor, and Rhizopus species. The test incorporates a monoclonal antibody TG11 which can also be used in immunohistochemistry to discriminate mucormycosis from aspergillosis.

Both of our lateral-flow tests are compatible with serum, bronchoalveolar lavage and other biofluids, providing a unique opportunity for the rapid point-of-care detection of this highly aggressive angio-invasive disease of humans.

Mucorales Enzyme Immunoassay

In addition to point-of-care lateral-flow tests, ISCA has developed an Enzyme Immunoassay (EIA) for the sensitive and specific detection of mucormycosis in humans. The EIA, which incorporates a newly developed pan-Mucorales-specific monoclonal antibody FH12, will be available soon as a research-use-only (RUO) kit.